Psychedelic Chemistry: The Psychedelic Potential of LSD Edibles

What is LSD?

LSD is a highly potent hallucinogen, which means it can alter a person’s view of reality and profoundly distort the senses. LSD came from “ergot,” a fungus on rye and other grains.

LSD is a complex chemical that belongs to the ergoline family at the molecular level. It comprises a bicyclic hexahydroindole group and a bicyclic quinoline group (lysergic acid). The name ‘Lysergic Acid Diethylamide’ is derived from the functional group attached to its core. LSD’s structure is comparable to those of other ergoline alkaloids, such as ergotamine, found in the ergot fungus Claviceps purpurea, as well as the neurotransmitter serotonin.

Effects of LSD

When people take LSD, it enters the brain and causes chemical responses that might persist for hours. LSD may have the following short-term effects:

  • Unpredictable mood fluctuations
  • Distorted reality
  • Dizziness.
  • Appetite loss.
  • Losing control of movement

What are the Benefits of LSD Use?

The benefits of LSD vary depending on the dosage you consume, with most studies focusing on the advantages of consuming smaller amounts of this psychedelic substance. Below, we’ve outlined the benefits associated with taking LSD.

Pain Control and Neuron Development

Researchers at Maastricht University discovered that a single microdose of LSD generated analgesic effects in their subjects for up to, and perhaps more than, five hours.

The Cold Pressor Test, which involves immersing your palm in 3°C (37.4°F) water for as long as possible, was conducted by participants. Those who took 20 mg of LSD immersed their hands for 20% longer than the control group and reported lower “subjective levels of perceived painfulness and unpleasantness.”

LSD can also aid in creating and expanding our brain’s 86 billion neurons. LSD drugs increase the level of BDNF in blood plasma in modest doses ranging from 5 to 20 ug. Mood disorders like depression, linked to neuroplasticity issues, might find some of LSD’s antidepressant effects attributed to its impact on neuronal health.

Improves Mental Health

Dr. Robin Carhart-Harris of Imperial College London developed the entropic brain hypothesis, which states that mental health issues are all caused by rigid thought processes maintained by a hyperactive default mode network (DMN). Psychedelic substances, such as LSD, break down the DMN, increasing entropy in the brain and allowing negative neural connections to break down and new positive patterns to develop.

A study of over 1,000 microdosers discovered a reduction in depression, while another big cross-sectional study discovered a reduction in negative mood and destructive attitudes and a surge in open-mindedness and knowledge.

Addiction Treatment

A meta-analysis of randomized-controlled clinical trials utilizing LSD in psychiatry discovered that LSD is most effective in treating alcoholism. This is also supported by the beneficial experiences of many patients treated for alcoholism under Humphrey Osmond and at the Spring Grove Hospital Centre in the 1950s and 1960s.

Relieve End-of-Life Anxiety and Depression

Dr. Peter Gasser discovered that LSD-assisted psychotherapy helped terminally sick cancer patients reduce their end-of-life anxiety. It also raised their subjective quality of life. A Phase 2 experiment is presently underway to evaluate the effect of LSD therapy on depression.

LSD Edibles: The Composition and How It’s Made

An LSD edible is an edible food or drink containing the hallucinogenic substance. These can range from chocolates and confectionery to cookies, cakes, and even LSD mints.

The Composition

  • LSD: The active compound responsible for the hallucinogenic effects. It is carefully measured and incorporated into the edible product.
  • Edible Base: The LSD is often dissolved or infused into a carrier substance, such as a gummy, candy, sugar cube, or other types of ingestible materials. These serve as the delivery mechanism for the psychoactive substance.
  • Flavouring and Ingredients: Depending on the specific edible product, there may be flavourings, sweeteners, and other ingredients added to enhance taste and texture. These vary widely and include natural or artificial flavourings, colours, and sugars.


  • LSD Synthesis: The first step involves the chemical synthesis of LSD. This synthesis requires a deep understanding of organic chemistry and access to precursor chemicals, equipment, and a laboratory.
  • Liquid Formulation: Once manufacturers synthesize LSD, they usually convert it into a liquid, often dissolving it in a solvent. This liquid serves as the concentrated LSD solution.
  • Infusion: Manufacturers infuse the liquid LSD into an edible carrier, such as gummy candies, sugar cubes, or blotter paper. The infused carrier absorbs the liquid, and it is possible to consume the LSD orally.
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